Progranulin and neuropathological features of Alzheimer's disease: longitudinal study

CONCLUSION: Our findings revealed that an increase in CSF progranulin over time is associated with faster formation of Aβ plaques in patients with only tau pathology based on the A/T/N classification (suspected non-Alzheimer's pathology). Together, our findings showed that the role of progranulin-related microglial activity on AD pathology can be stage-dependent, complicated, and more prominent in non-AD pathologic changes. Thus, there is a need for further studies to consider progranulin-based therapies for AD treatment.PMID:38441695 | DOI:10.1007/s40520-024-02715-9
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Source Type: research