Cancers, Vol. 16, Pages 1052: Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study)

Cancers, Vol. 16, Pages 1052: Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study) Cancers doi: 10.3390/cancers16051052 Authors: Sonja Aho Emerik Osterlund Ari Ristimäki Lasse Nieminen Jari Sundström Markus J. Mäkinen Teijo Kuopio Soili Kytölä Annika Ålgars Raija Ristamäki Eetu Heervä Raija Kallio Päivi Halonen Leena-Maija Soveri Arno Nordin Aki Uutela Tapio Salminen Hanna Stedt Annamarja Lamminmäki Timo Muhonen Juha Kononen Bengt Glimelius Helena Isoniemi Juho T. Lehto Kaisa Lehtomäki Pia Osterlund The primary tumor location (PTL) is associated with the phenotype, metastatic sites, mutations, and outcomes of metastatic colorectal cancer (mCRC) patients, but this has mostly been studied according to sidedness (right vs. left sided). We studied right colon vs. left colon vs. rectal PTL in a real-life study population (n = 1080). Health-related quality of life (HRQoL) was assessed multi-cross-sectionally with QLQ-C30, QLQ-CR29, EQ-5D, and 15D. A chi-square, Kaplan–Meier, and Cox regression were used to compare the groups. The PTL was in the right colon in 310 patients (29%), the left colon in 396 patients (37%), and the rectum in 375 patients (35%). The PTL was associated with distinct differences in metastatic sites during the disease trajectory. The resectability, con...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research