Early Experience With Devices That Reduce Kidney Vascular Afterload From The Veins

Worsening renal failure due to cardiorenal syndrome (CRS) is noted in nearly one-third of acute decompensated heart failure (ADHF) admissions (1). The pathophysiology of CRS in patients with ADHF is a self-perpetuating cycle attributed to both poor renal artery perfusion, or “preload,” as well as increased renal venous congestion, or “afterload.” The etiology of reduced renal artery preload is multifactorial. Low cardiac output, activation of the renin-angiotensin-aldosterone system, and hypotension, lead to a compensatory vasoconstriction of the renal artery an d glomerular afferent arterioles as the kidney attempts to maintain a constant glomerular filtration rate (GFR) (2).

Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Alexander M. Spring, Enklajd Marsela, Ulrich P. Jorde Tags: JCF Ignite! Source Type: research