Genetic diversity promotes resilience in a mouse model of Alzheimer's disease

DISCUSSION: Increasing genetic diversity promotes resilience to AD-related pathogenesis, relative to an inbred C57BL/6J background, reinforcing the importance of genetic diversity in uncovering resilience in the development of AD.HIGHLIGHTS: Genetic diversity's impact on AD in mice was explored. Diverse F1 mouse strains were used for AD study, via the Collaborative Cross. Strain-specific variations in AD pathology, glia, and transcription were found. Strains resilient to plaque formation and plasma neurofilament light chain (NfL) increases were identified. Correlations with human AD transcriptomics were observed.PMID:38426371 | DOI:10.1002/alz.13753

Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Neelakshi Soni Lindsay A Hohsfield Kristine M Tran Shimako Kawauchi Amber Walker Dominic Javonillo Jimmy Phan Dina Matheos Celia Da Cunha Asli Uyar Giedre Milinkeviciute Angela Gomez-Arboledas Katelynn Tran Catherine C Kaczorowski Marcelo A Wood Andrea J Source Type: research