Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents

This study provided a successful example of crystal structure-guided discovery of 5i as a colchicine-targeted tubulin degradation agent, expanding the scope of targeted protein degradation.PMID:38430854 | DOI:10.1016/j.ejmech.2024.116265

Source: European Journal of Medicinal Chemistry - March 2, 2024 Category: Chemistry Authors: Chufeng Zhang Wei Yan Yan Liu Minghai Tang Yaxin Teng Fang Wang Xiuying Hu Min Zhao Jianhong Yang Yong Li Source Type: research