Obesity-related glomerulopathy: recent advances in inflammatory mechanisms and related treatments

J Leukoc Biol. 2024 Mar 1:qiae035. doi: 10.1093/jleuko/qiae035. Online ahead of print.ABSTRACTObesity-related glomerulopathy (ORG), which is an obesity-triggered kidney damage, has become a significant threat to human health. Several studies have recently highlighted the critical role of inflammation in ORG development. Additionally, excess adipose tissue and adipocytes in patients with obesity produce various inflammatory factors that cause systemic low-grade inflammation with consequent damage to vascular endothelial cells, exacerbating glomerular injury. Therefore, we conducted a comprehensive review of ORG and addressed the critical role of obesity-induced chronic inflammation in ORG pathogenesis and progression, which leads to tubular damage and proteinuria, ultimately impairing renal function. The relationship between obesity and ORG is facilitated by a network of various inflammation-associated cells (including macrophages, lymphocytes, and mast cells) and a series of inflammatory mediators (such as tumor necrosis factor-alpha, interleukin-6, leptin, adiponectin, resistin, chemokines, adhesion molecules, and plasminogen activator inhibitor-1) and their inflammatory pathways. Furthermore, we discuss a recently discovered relationship between micronutrients and ORG inflammation and the important role of micronutrients in the body's anti-inflammatory response. Therefore, assessing these inflammatory molecules and pathways will provide a strong theoretical basis for develo...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Source Type: research