Galectin-3 levels in children with cystic fibrosis

Conclusion: The study shows that serum Galectin-3 levels increased in clinically stable CF patients, and serum Galectin-3 response may depend on age, gender, and BMI. The sputum Galectin-3 was found to be negatively correlated with patients ’ lung functions.What is known:• Galectin-3 is a key regulator of chronic inflammation in the lung, liver, kidney, and tumor microenvironment.What is new:• Children with cystic fibrosis (CF) have higher serum Galectin-3 concentrations than healthy children.• Serum Galectin-3 expression influenced by age, BMI, and gender in children with CF.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research