A case of hereditary dementia: Is it Alzheimer's disease or not?

Frontotemporal Dementia (FTD) and Alzheimer's disease (AD) are among the main causes of early-onset and hereditary dementia, and the distinction between the two has repercussions for therapeutic choices and prognostic evaluations. While early-onset AD is more often sporadic, the likelihood of genetic mutations underlying FTD is considerably increased even in non-familial cases, which has important consequences for families and caregivers. Some FTD-associated genes interact with the metabolism of AD-related proteins, and the progress in molecular knowledge shed light on novel genetic variants and new genotype-phenotype correlations, opening to possible confounders in the clinical setting [1].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research