Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence

CONCLUSIONS: Our findings add to emerging evidence linking the FAAH C385A variant to lower risk of psychopathology, and extend these findings to a developmental sample. In particular, we found lower depressive symptoms in FAAH AA genotypes compared to AC and CC genotypes. Future research is needed to characterize the role of the FAAH variant and the eCB system more broadly in neurodevelopment and psychiatric risk.PMID:38423255 | DOI:10.1016/j.bbr.2024.114925

Source: Behavioural Brain Research - February 29, 2024 Category: Neurology Authors: Shreya Desai Clara G Zundel Julia M Evanski Leah C Gowatch Amanpreet Bhogal Samantha Ely Carmen Carpenter MacKenna Shampine Emilie O'Mara Christine A Rabinak Hilary A Marusak Source Type: research