Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems

We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated to the early intervention - patient's adherence and compliance, side effects, relapse - and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the possibility of drug targeting to a specific compartment, reducing side effects upon systemic administration.PMID:38403255 | DOI:10.1016/j.addr.2024.115218
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Source Type: research