Mitochondrial dysfunction in lipid processing and gastrointestinal disorders

Trends Endocrinol Metab. 2024 Feb 27:S1043-2760(24)00038-9. doi: 10.1016/j.tem.2024.02.009. Online ahead of print.ABSTRACTMitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in Nature, Moschandrea et al. used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and transport. Their work sheds light on the development of gastrointestinal disorders as a result of mitochondrial dysfunction.PMID:38418280 | DOI:10.1016/j.tem.2024.02.009
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research