Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors

ConclusionsWe confirmed high prevalence of USP8 mutations and low incidence of USP48 and TP53 mutations. Changes in protein deubiquitinases genes appear to be favorable prognostic factors in CD. TP53 mutations are rare, occur in both functioning and silent tumors and are related to poor clinical outcome in CD.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research