Long-term lymphocyte subset number reconstitution is unique but comparable between umbilical cord blood and unrelated bone marrow transplantation

In this study, we analyzed lymphocyte subset (LST) number to determine the long-term recovery timeline. We included 36 U-CBT and 10 unrelated bone marrow transplantation (U-BMT) recipients who survived more than 2 years after transplantation, and followed them for up to 10 years post-transplant. Recovery kinetics in the early phase post-transplant was different for each LST. Recovery of CD19+ B cells was faster after U-CBT than after U-BMT in the first 5 years after transplantation. Although CD4+ T cells increased in the first several months after U-CBT, long-term cell count recovery was impaired in approximately 20% of patients. Thus, although the LST recovery pattern after U-CBT was unique, LST number recovery was statistically comparable between U-CBT and U-BMT past 5 years post-transplantation.PMID:38407785 | DOI:10.1007/s12185-024-03727-x

Source: International Journal of Hematology - February 26, 2024 Category: Hematology Authors: Keiko Tsumita Shinsuke Takagi Yuki Asano-Mori Otoya Watanabe Michiho Shindo Kyosuke Yamaguchi Mitsuhiro Yuasa Kosei Kageyama Daisuke Kaji Yuki Taya Aya Nishida Kazuya Ishiwata Hisashi Yamamoto Hideki Araoka Go Yamamoto Shigeyoshi Makino Atsushi Wake Naoyu Source Type: research