Effect of High Altitude Environment on Pharmacokinetic and Pharmacodynamic of Warfarin in Rats

CONCLUSION: High altitude environment inhibited the metabolism and increased the absorption of warfarin in rats and increased the effect of anticoagulant effect, suggesting that the optimal dose of warfarin for patients at high altitude should be reassessed.PMID:38409697 | DOI:10.2174/0113892002277930240201101256

Source: Current Drug Metabolism - February 27, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Zhang Hongfang Mu Yan Zhong Rong Wang Wenbin Li Source Type: research