RAS-Mutated Cytologically Indeterminate Thyroid Nodules: Prevalence of Malignancy and Behavior Under Active Surveillance

CONCLUSIONS: We describe the behavior of RAS-mutant ITNs under AS and find that most demonstrate stability over time. Of the resected RAS-mutant nodules, most were benign; of the cancers, most were ATA low-risk. Immediate surgical resection of all RAS-mutant ITNs appears to be a low-value practice. Further research is needed to help define cases most appropriate for AS or immediate surgery.PMID:38407967 | DOI:10.1089/thy.2023.0544

Source: Thyroid : official journal of the American Thyroid Association - February 26, 2024 Category: Endocrinology Authors: Hannah J Sfreddo Elizabeth S Koh Karena Zhao Christina E Swartzwelder Brian R Untch Jennifer L Marti Benjamin R Roman Jared Dublin Ronald Wang Rong Xia Jean-Marc Cohen Bin Xu Ronald Ghossein Babak Givi Jay O Boyle R Michael Tuttle James A Fagin Richard J Source Type: research