mRNA Expression and Methylation of the < em > RAD51 < /em > , < em > ATM < /em > , < em > ATR < /em > , < em > BRCA1 < /em > , and < em > BRCA2 < /em > Genes in Gastric Adenocarcinoma

CONCLUSIONS: Our results suggest RAD51, BRCA1, and BRCA2 methylation as a frequent epigenetic mechanism in gastric cancer, support the hypothesis that reduced BRCA1 expression participates in disease progression, and show an association between RAD51 mRNA and perineural invasion and mortality that may be considered unexpected, considering the former immunohistochemical studies. The lack of correlation between immunohistochemistry and mRNA, and even the inverse association, for ATR, can be seen as indicative of action of post-transcriptional or post-translational regulatory mechanisms, to be better investigated.PMID:38293680 | PMC:PMC10826385 | DOI:10.1177/11772719231225206

Source: Biomarker Insights - January 31, 2024 Category: General Medicine Authors: Joel Del Bel P ádua Carolline Fontes Alves Mariano Alexandre Todorovic Fabro Fermino Sanches Lizarte Neto Rog ério Lenotti Zuliani Cl áudia Tarcila Gomes Sares Jos é Sebastião Dos Santos Ajith Kumar Sankarankutty Daniela Pretti da Cunha Tirapelli Van Source Type: research