Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer
CONCLUSIONS: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement.REGISTRATION: Australian and New Zealand Clinical Trials Registry #12611000318987.PMID:38426070 | PMC:PMC10903227 | DOI:10.1177/11772719241232870 (Source: Biomarker Insights)
Source: Biomarker Insights - March 1, 2024 Category: General Medicine Authors: Hiba Al Naji Jean M Winter Susanne K Pedersen Amitesh Roy Susan E Byrne Graeme P Young Erin L Symonds Source Type: research

mRNA Expression and Methylation of the < em > RAD51 < /em > , < em > ATM < /em > , < em > ATR < /em > , < em > BRCA1 < /em > , and < em > BRCA2 < /em > Genes in Gastric Adenocarcinoma
CONCLUSIONS: Our results suggest RAD51, BRCA1, and BRCA2 methylation as a frequent epigenetic mechanism in gastric cancer, support the hypothesis that reduced BRCA1 expression participates in disease progression, and show an association between RAD51 mRNA and perineural invasion and mortality that may be considered unexpected, considering the former immunohistochemical studies. The lack of correlation between immunohistochemistry and mRNA, and even the inverse association, for ATR, can be seen as indicative of action of post-transcriptional or post-translational regulatory mechanisms, to be better investigated.PMID:3829368...
Source: Biomarker Insights - January 31, 2024 Category: General Medicine Authors: Joel Del Bel P ádua Carolline Fontes Alves Mariano Alexandre Todorovic Fabro Fermino Sanches Lizarte Neto Rog ério Lenotti Zuliani Cl áudia Tarcila Gomes Sares Jos é Sebastião Dos Santos Ajith Kumar Sankarankutty Daniela Pretti da Cunha Tirapelli Van Source Type: research

mRNA Expression and Methylation of the < em > RAD51 < /em > , < em > ATM < /em > , < em > ATR < /em > , < em > BRCA1 < /em > , and < em > BRCA2 < /em > Genes in Gastric Adenocarcinoma
CONCLUSIONS: Our results suggest RAD51, BRCA1, and BRCA2 methylation as a frequent epigenetic mechanism in gastric cancer, support the hypothesis that reduced BRCA1 expression participates in disease progression, and show an association between RAD51 mRNA and perineural invasion and mortality that may be considered unexpected, considering the former immunohistochemical studies. The lack of correlation between immunohistochemistry and mRNA, and even the inverse association, for ATR, can be seen as indicative of action of post-transcriptional or post-translational regulatory mechanisms, to be better investigated.PMID:3829368...
Source: Biomarker Insights - January 31, 2024 Category: General Medicine Authors: Joel Del Bel P ádua Carolline Fontes Alves Mariano Alexandre Todorovic Fabro Fermino Sanches Lizarte Neto Rog ério Lenotti Zuliani Cl áudia Tarcila Gomes Sares Jos é Sebastião Dos Santos Ajith Kumar Sankarankutty Daniela Pretti da Cunha Tirapelli Van Source Type: research

mRNA Expression and Methylation of the < em > RAD51 < /em > , < em > ATM < /em > , < em > ATR < /em > , < em > BRCA1 < /em > , and < em > BRCA2 < /em > Genes in Gastric Adenocarcinoma
CONCLUSIONS: Our results suggest RAD51, BRCA1, and BRCA2 methylation as a frequent epigenetic mechanism in gastric cancer, support the hypothesis that reduced BRCA1 expression participates in disease progression, and show an association between RAD51 mRNA and perineural invasion and mortality that may be considered unexpected, considering the former immunohistochemical studies. The lack of correlation between immunohistochemistry and mRNA, and even the inverse association, for ATR, can be seen as indicative of action of post-transcriptional or post-translational regulatory mechanisms, to be better investigated.PMID:3829368...
Source: Biomarker Insights - January 31, 2024 Category: General Medicine Authors: Joel Del Bel P ádua Carolline Fontes Alves Mariano Alexandre Todorovic Fabro Fermino Sanches Lizarte Neto Rog ério Lenotti Zuliani Cl áudia Tarcila Gomes Sares Jos é Sebastião Dos Santos Ajith Kumar Sankarankutty Daniela Pretti da Cunha Tirapelli Van Source Type: research

mRNA Expression and Methylation of the < em > RAD51 < /em > , < em > ATM < /em > , < em > ATR < /em > , < em > BRCA1 < /em > , and < em > BRCA2 < /em > Genes in Gastric Adenocarcinoma
CONCLUSIONS: Our results suggest RAD51, BRCA1, and BRCA2 methylation as a frequent epigenetic mechanism in gastric cancer, support the hypothesis that reduced BRCA1 expression participates in disease progression, and show an association between RAD51 mRNA and perineural invasion and mortality that may be considered unexpected, considering the former immunohistochemical studies. The lack of correlation between immunohistochemistry and mRNA, and even the inverse association, for ATR, can be seen as indicative of action of post-transcriptional or post-translational regulatory mechanisms, to be better investigated.PMID:3829368...
Source: Biomarker Insights - January 31, 2024 Category: General Medicine Authors: Joel Del Bel P ádua Carolline Fontes Alves Mariano Alexandre Todorovic Fabro Fermino Sanches Lizarte Neto Rog ério Lenotti Zuliani Cl áudia Tarcila Gomes Sares Jos é Sebastião Dos Santos Ajith Kumar Sankarankutty Daniela Pretti da Cunha Tirapelli Van Source Type: research