Molecules, Vol. 29, Pages 1018: Kombucha as a Potential Active Ingredient in Cosmetics & mdash;An Ex Vivo Skin Permeation Study

Molecules, Vol. 29, Pages 1018: Kombucha as a Potential Active Ingredient in Cosmetics—An Ex Vivo Skin Permeation Study Molecules doi: 10.3390/molecules29051018 Authors: Karolina Jakubczyk Anna Nowak Anna Muzykiewicz-Szymańska Łukasz Kucharski Kinga Szymczykowska Katarzyna Janda-Milczarek Kombucha is a non-alcoholic beverage, that is increasingly used in the cosmetic industry. The available literature reports the positive effects of kombucha on the skin, in particular its antioxidant action. However, there is a lack of information on skin permeation and the accumulation of active ingredients showing such effects. Skin aging is largely dependent on oxidative stress, therefore in our study we assessed the ex vivo permeation of two types of kombucha (green and black tea) through porcine skin. The antioxidant activity (DPPH, ABTS, FRAP methods) and total polyphenol content of these extracts were determined before and after permeation testing. Moreover, the content of selected phenolic acids as well as caffeine was assessed. Skin permeation was determined using a Franz diffusion cell. The antioxidant activity of both Kombuchas was found to be high. In addition, gallic acid, chlorogenic acid, protocatechuic acid, coumaric acid, m-hydroxybenzoic acid, and caffeine were identified. A 24-h ex vivo study showed the permeation of some phenolic acids and caffeine and their accumulation in the skin. Our results confirm the importance of studying the skin perm...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research