Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance

CONCLUSIONS: Drp1-mediated mitochondrial quality imbalance is a potential therapeutic target for sepsis. Small molecule natural drugs like NGR1 targeting Drp1 may offer new directions for organ protection following sepsis. Future research should focus on clinical trials to evaluate NGR1's efficacy across various patient populations, potentially leading to novel treatments for sepsis.PMID:38389274 | DOI:10.1080/13880209.2024.2318349

Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Dongyao Hou Ruixue Liu Shuai Hao Yong Dou Guizhen Chen Liangming Liu Tao Li Yunxing Cao He Huang Chenyang Duan Source Type: research