Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis

CONCLUSIONS: Overall, our findings suggest that DOCK7 delivered via TAM-EVs could regulate cholesterol metabolism in CRC cells and CRC cell metastasis through the RAC1/AKT/FOXO1/ABCA1 axis. DOCK7 could thus be a new therapeutic target for controlling CRC metastasis.PMID:38385857 | PMC:PMC10883245 | DOI:10.1002/ctm2.1591

Source: Clinical Colorectal Cancer - February 22, 2024 Category: Cancer & Oncology Authors: Weiwei Chen Menghua Zhou Bingjie Guan Bowen Xie Youdong Liu Jiang He Jingjing Zhao Qian Zhao Dongwang Yan Source Type: research