Methyl gallate from < em > Camellia nitidissima < /em > Chi flowers reduces quorum sensing related virulence and biofilm formation against < em > Aeromonas hydrophila < /em >

This study aimed to extract methyl gallate (MG) from the flowers of Camellia nitidissima Chi and evaluate its potential as a quorum sensing inhibitor (QSI) against Aeromonas hydrophila SHAe 115. MG reduced QS-associated virulence factors, including hemolysis, protease, and lipase, while impairing swimming motility and biofilm formation. Additionally, MG down-regulated positive regulatory genes (ahyR, fleQ) and up-regulated negative regulators (litR, fleN). This highlights MG's promise as a potent QSI for A. hydrophila SHAe 115, advancing strategies against infections in aquaculture and human health.PMID:38373897 | DOI:10.1080/08927014.2024.2316611
Source: Biofouling - Category: Molecular Biology Authors: Source Type: research