The potential roles of salivary biomarkers in neurodegenerative diseases

Neurobiol Dis. 2024 Feb 19:106442. doi: 10.1016/j.nbd.2024.106442. Online ahead of print.ABSTRACTCurrent research efforts on neurodegenerative diseases are focused on identifying novel and reliable biomarkers for early diagnosis and insight into disease progression. Salivary analysis is gaining increasing interest as a promising source of biomarkers and matrices for measuring neurodegenerative diseases. Saliva collection offers multiple advantages over the currently detected biofluids as it is easily accessible, non-invasive, and repeatable, allowing early diagnosis and timely treatment of the diseases. Here, we review the existing findings on salivary biomarkers and address the potential value in diagnosing neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Amyotrophic lateral sclerosis. Based on the available research, β-amyloid, tau protein, α-synuclein, DJ-1, Huntington protein in saliva profiles display reliability and validity as the biomarkers of neurodegenerative diseases.PMID:38382884 | DOI:10.1016/j.nbd.2024.106442
Source: Neurobiology of Disease - Category: Neurology Authors: Source Type: research