Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis
CONCLUSIONS: Overall, our findings suggest that DOCK7 delivered via TAM-EVs could regulate cholesterol metabolism in CRC cells and CRC cell metastasis through the RAC1/AKT/FOXO1/ABCA1 axis. DOCK7 could thus be a new therapeutic target for controlling CRC metastasis.PMID:38385857 | DOI:10.1002/ctm2.1591
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Weiwei Chen Menghua Zhou Bingjie Guan Bowen Xie Youdong Liu Jiang He Jingjing Zhao Qian Zhao Dongwang Yan Source Type: research
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