Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes

ConclusionThe signaling axis TRAF‐6/TAK‐1/MKK‐4/JNK‐2 mediates IL‐1–induced aggrecanolysis. The level of aggrecanase is controlled by its endocytosis, which may be reduced upon IL‐1 stimulation because of LRP‐1 shedding.

Source: Arthritis and Rheumatism - June 26, 2015 Category: Rheumatology Authors: Heba M. Ismail, Kazuhiro Yamamoto, Tonia L. Vincent, Hideaki Nagase, Linda Troeberg, Jeremy Saklatvala Tags: Chondrocyte Biology Source Type: research