Adenoid cystic carcinoma of the Bartholin's gland is underpinned by MYB- and MYBL1- rearrangements

CONCLUSIONS: AdCC-BGs constitute a convergent phenotype, whereby activation of MYB or MYBL1 can be driven by the MYB::NFIB fusion gene or MYBL1 rearrangements. Our observations further support the notion that AdCCs, irrespective of organ site, constitute a genotypic-phenotypic correlation. Assessment of MYB or MYBL1 rearrangements may be used as an ancillary marker for the diagnosis of AdCC-BGs.PMID:38368814 | DOI:10.1016/j.ygyno.2024.02.015

Source: Gynecologic Oncology - February 18, 2024 Category: Cancer & Oncology Authors: Jacqueline Feinberg Arnaud Da Cruz Paula Edaise M da Silva Fresia Pareja Juber Patel Yingjie Zhu Pier Selenica Mario M Leitao Nadeem R Abu-Rustum Jorge S Reis-Filho Amy Joehlin-Price Britta Weigelt Source Type: research