Validation of a methylation-based signature for subventricular zone involvement in glioblastoma

ConclusionHerein, we validated the specific epigenetic signature in GBM in the vicinity of the SVZ and highlighted the importance of methylation of a part of the LRBA/MAB21L2 gene locus. Whether SVZM can replace MRI-based SVZ assignment as a prognostic and diagnostic tool will require prospective studies of large, homogeneous cohorts.

http://link.springer.com/10.1007/s11060-024-04570-0

Source: Journal of Neuro-Oncology - February 20, 2024 Category: Cancer & Oncology Source Type: research