Distinct Developmental Reprogramming Footprint of MacrophagesDuring Acute Kidney Injury Across Species

Am J Physiol Renal Physiol. 2024 Feb 15. doi: 10.1152/ajprenal.00013.2024. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who are critically ill. Development of AKI is associated with several adverse outcomes including mortality, morbidity, progression to chronic kidney disease, and increase in health care expenditure. Despite the well-established negative impact of AKI and rigorous efforts to better define, identify, and implement targeted therapies, the overall approach to treatment of AKI continues to principally encompass supportive measures. This enduring challenge is primarily due to the heterogenous nature of insults that activate many independent and overlapping molecular pathways. Consequently, it is evident that identification of common mechanisms that mediate pathogenesis of AKI, independent of etiology and engaged pathophysiologic pathways, is of paramount importance and could lead to identification of novel therapeutic targets. To better distinguish the commonly modulated mechanisms of AKI we explored transcriptional characteristics of human kidney biopsies from patients with acute tubular necrosis (ATN), and acute interstitial nephritis (AIN) using a NanoString inflammation panel. Subsequently, we utilized publicly available single-cell transcriptional resources to better interpret the generated transcriptional findings. Our findings identify robust AKI-induced developmental reprogramming ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Source Type: research