Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate

We report that allogeneic transplantation of genetically engineered (B2M-/-, CIITA-/-, CD47+), primary, hypoimmune, pseudo-islets (p-islets) results in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provide stable endocrine function and enable insulin independence without inducing any detectable immune response in the absence of immunosuppression. Hypoimmune primary p-islets may provide a curative cell therapy for type 1 diabetes mellitus.PMID:38335966 | DOI:10.1016/j.stem.2024.02.001

Source: Cell Stem Cell - February 9, 2024 Category: Stem Cells Authors: Xiaomeng Hu Kathy White Chi Young Ari G Olroyd Paul Kievit Andrew J Connolly Tobias Deuse Sonja Schrepfer Source Type: research