The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes

In conclusion, our results provide evidence that reducing endogenous tPA following recanalization improves functional outcomes and reduces post-stroke brain damage.PMID:38360257 | DOI:10.1016/j.expneurol.2024.114727

Source: Experimental Neurology - February 15, 2024 Category: Neurology Authors: Siva Reddy Challa Koteswara Rao Nalamolu Casimir A Fornal Isidra M Baker Adithya Mohandass Sahil Reddy Mada Billy C Wang David M Pinson Sourabh Lahoti Jeffrey D Klopfenstein Krishna Kumar Veeravalli Source Type: research