Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway

Adv Drug Deliv Rev. 2024 Feb 7:115196. doi: 10.1016/j.addr.2024.115196. Online ahead of print.ABSTRACTWe overviewed the anatomy and physiology of the nose-to-brain pathway, along with the mechanisms involved. We then summarized the interaction process between nanoparticles and this pathway as well as the potential strategies inspired from natural nano-sized substances. This review may help inspire the potential of intranasal drug delivery in the application to treat various brain diseases. Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.PMID:38336090 | DOI:10.1016/j.addr.2024.115196
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Source Type: research