Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation

Cardiac glucose oxidation is decreased in heart failure with reduced ejection fraction (HFrEF), contributing to a decrease in myocardial ATP production. In contrast, circulating ketones and cardiac ketone oxidation are increased in HFrEF. Since ketones compete with glucose as a fuel source, we aimed to determine whether increasing ketone concentration both chronically with the SGLT2 inhibitor, dapagliflozin, or acutely in the perfusate has detrimental effects on cardiac glucose oxidation in HFrEF, and what effect this has on cardiac ATP production.

Source: Metabolism - Clinical and Experimental - February 16, 2024 Category: Biomedical Science Authors: Simran Pherwani, David Connolly, Qiuyu Sun, Qutuba G. Karwi, Michael Carr, Kim L. Ho, Cory S. Wagg, Liyan Zhang, Jody Levasseur, Heidi Silver, Jason R.B. Dyck, Gary D. Lopaschuk Source Type: research