COVID-19 plasma induces subcellular remodelling within the pulmonary microvascular endothelium

CONCLUSION AND IMPACT: During COVID-19, the pMV undergoes significant remodelling, which is evident based on the functional, phenotypic, and transcriptional changes seen following exposure to COVID-19 plasma. The observed morphological variation may be responsible for downstream complications, such as a decline in overall cellular function and cell-to-cell barrier integrity. Moreover, genes identified through bulk RNA sequencing may contribute to our understanding of the observed phenotype and assist in developing strategies that can inform the rescue of the dysregulated endothelium.PMID:38266794 | DOI:10.1016/j.vph.2024.107277

Source: Vascular Pharmacology - January 24, 2024 Category: Drugs & Pharmacology Authors: Rainha Passi Justyna Cholewa-Waclaw Ryan Wereski Matthew Bennett Stefan Veizades Bronwyn Berkeley Andrea Caporali Ziwen Li Julie Rodor Mieke Dewerchin Nicholas L Mills Abdelaziz Beqqali Mairi Brittan Andrew H Baker Source Type: research