Expression of IL-17RA in Innate Cells of Patients with Common Variable Immunodeficiency (CVID) and its Clinical Implications

Conclusions. The study suggests that despite previous reports of reduced circulating Th17 cells and IL-17 levels in CVID patients, IL-17RA expression in innate cells may be elevated, potentially indicating altered IL-17 signaling. This heightened IL-17RA expression could contribute to a persistent pro-inflammatory state, possibly due to microbial translocation or other inflammatory factors. The association of IL-17RA expression with gastrointestinal microbial colonization and its correlation with fecal calprotectin underscores the complexity of IL-17RA's role in CVID pathophysiology. Further research in larger cohorts could elucidate the implications of IL-17RA expression in both infectious and non-infectious inflammatory aspects of CVID.PMID:38259136 | DOI:10.23822/EurAnnACI.1764-1489.326

Source: European Annals of Allergy and Clinical Immunology - January 23, 2024 Category: Allergy & Immunology Authors: P Botelho Alves H Pires Pereira J Costa Carvalho I Nunes A Todo-Bom E Faria F Regateiro A Paiva Source Type: research