Clinicopathological characterisation of < em > MTAP < /em > alterations in gastrointestinal cancers

CONCLUSIONS: MTAP alterations are found in 5%-10% of GI cancers, most frequently biliopancreatic and gastro-oesophageal. MTAP loss is the most common alteration, identified almost exclusively in MSS, CDKN2A/B loss, upper-GI cancers. Other MTAP alterations were found in colorectal cancer, but unlikely to cause protein loss and drug susceptibility.PMID:38350716 | DOI:10.1136/jcp-2023-209341

Source: Clinical Colorectal Cancer - February 13, 2024 Category: Cancer & Oncology Authors: Gianluca Mauri Giorgio Patelli Laura Roazzi Emanuele Valtorta Alessio Amatu Giovanna Marrapese Erica Bonazzina Federica Tosi Katia Bencardino Gabriele Ciarlo Elisa Mariella Silvia Marsoni Alberto Bardelli Emanuela Bonoldi Andrea Sartore-Bianchi Salvatore Source Type: research