M6A methylation-regulated autophagy may be a new therapeutic target for intervertebral disc degeneration
This article first summarizes the effects of various stressors on the death and autophagy of nucleus pulposus cells. Then, it summarizes the regulatory mechanism of m6A methylation on autophagy-related genes under stress and the role of these autophagy genes in nucleus pulposus cells. Finally, it proposes that the methylation modification of autophagy-related genes regulated by m6A may become a new treatment approach for intervertebral disc degeneration, providing new insights and ideas for the clinical treatment of intervertebral disc degeneration.PMID:38317355 | DOI:10.1002/cbin.12135
Source: Cell Biology International - Category: Cytology Authors: Yuao Tao Xiaoyu Yu Xiaolong Li Yuzhu Xu Hui Wang Lele Zhang Rubing Lin Yuntao Wang Pan Fan Source Type: research
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