A novel NMDA receptor modulator: the antidepressant effect and mechanism of GW043

CONCLUSION: Our findings disclose that GW043, as a partial agonist of NMDAR, can reverse depression-like behaviors in rats by modulating synaptic plasticity, indicating its potential as an antidepressant agent.PMID:38332552 | PMC:PMC10853642 | DOI:10.1111/cns.14598

Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Murezati Tiliwaerde Nana Gao Yaqi Yang Zengliang Jin Source Type: research