Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF- κB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress

CONCLUSIONS: The upregulation of PTP1B induced by SNI facilitates the activation of NF-κB and glial cells via ER stress in the spinal dorsal horn. This, in turn, leads to an increase in the production of pro-inflammatory cytokines, thereby contributing to the development and maintenance of neuropathic pain. Therefore, targeting PTP1B could be a promising therapeutic strategy for the treatment of neuropathic pain.PMID:38334011 | PMC:PMC10853896 | DOI:10.1111/cns.14609
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research