Role of microsomal metabolism in bromfenac-induced cytotoxicity

In conclusion, this research sheds light on the metabolic intricacies leading to cytotoxicity induced by bromfenac, especially emphasizing the role of UGT-dependent metabolism and the formation of reactive intermediates like bromfenac lactam. These findings offer insight into the mechanistic basis of DILI and emphasize the importance of understanding metabolism-mediated toxicity.PMID:38331335 | DOI:10.1016/j.cbi.2024.110903
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Source Type: research