Inhibition of AMPK activation in < em > Echinococcus granulosus < /em > sensu stricto limits the parasite's glucose metabolism and survival

In this study, we found that targeted knockdown of EgAMPKα or a small-molecule AMPK inhibitor inhibited the viability of E. granulosus sensu stricto (s.s.) and disrupted the ultrastructure. The results of in vivo experiments showed that the AMPK inhibitor had a significant therapeutic effect on E. granulosus s.s.-infected mice and resulted in the loss of cellular structures of the germinal layer. In addition, the inhibition of the EgAMPK/EgGLUT1 pathway limited glucose uptake and glucose metabolism functions in E. granulosus s.s.. Overall, our results suggest that EgAMPK can be a potential drug target for CE and that inhibition of EgAMPK activation is an effective strategy for the treatment of disease.PMID:38349157 | DOI:10.1128/aac.01202-23

Source: Antimicrobial Agents and Chemotherapy - February 13, 2024 Category: Microbiology Authors: Mingzhi Yan Hui Liu Yansen Su Xiaojuan Bi Ning Yang Renyong Lin Guodong L ü Source Type: research