Aminic Organoselenium Compounds as Glutathione Peroxidase Mimics and Inhibitors of Ferroptosis

This study revealed that the methoxy-substituted organoselenium compounds showed significant effect on the GPx-like activity. The catalytic parameters for the most efficient catalysts were also determined. The anti-ferroptotic activity for all GPx-mimics evaluated in a 4-OH-tamoxifen (TAM) inducible GPx4 knockout cell line using liproxstatin as standard.PMID:38293899 | DOI:10.1002/cbic.202400074

https://pubmed.ncbi.nlm.nih.gov/38293899/?utm_source=no_user_agent&utm_medium=rs...

Source: Chembiochem - January 31, 2024 Category: Biochemistry Authors: Babli Chhillar Rajni Kadian Manish Kumar Manisha Yadav Nikhil Sodhi Thamara Nishida Xavier da Silva Jose Pedro Friedmann Angeli Vijay P Singh Source Type: research