Gut microbiota dysbiosis and intestinal barrier impairment in diarrhea caused by cold drink and high-fat diet

In conclusion, impaired gut microbial and mechanical barrier function is responsible for CDHFD-induced diarrhea. In this study, we constructed a model of diet-induced diarrhea by simulating human dietary patterns, evaluated the long-term effects of CDHFD on human intestinal barriers and immune systems, and revealed its mechanism of action based on chronic inflammation. This study validated the model's fit to provide an effective screening model for drug or functional food development.PMID:38216112 | DOI:10.1016/j.tox.2024.153728

Source: Toxicology - January 12, 2024 Category: Toxicology Authors: Yajuan Tian Meng Fu Jie Su Meiqiu Yan Jingjing Yu Chenxing Wang Zhuangwei Niu Yuzhong Du Xueling Hu Jiayi Zheng Bai Tao Zengguang Gao Jianzhen Chen Suhong Chen Guiyuan Lv Source Type: research