JCAD Deficiency Attenuates Activation of Hepatic Stellate Cells and Cholestatic Fibrosis

CONCLUSION: JCAD deficiency effectively suppressed hepatic fibrosis induced by BDL in mice, and the underlying mechanisms are largely through suppressed Hippo-YAP signaling activity in HSCs.PMID:38190829 | DOI:10.3350/cmh.2023.0506

Source: Clinical and molecular hepatology - January 8, 2024 Category: Gastroenterology Authors: Li Xie Hui Chen Li Zhang Yue Ma Yuan Zhou Yong-Yu Yang Chang Liu Yu-Li Wang Ya-Jun Yan Jia Ding Xiao Teng Qiang Yang Xiu-Ping Liu Jian Wu Source Type: research