Downregulation of TET2 contributes to nasal polypogenesis through HIF1 α-mediated epithelial-to-mesenchymal transition

CONCLUSION: TET2 was negatively correlated with HIF1α and EMT in vivo. Moreover, TET2 was down-regulated by HIF1α, resulting in EMT in CoCl2-hypoxia hNECs via regulation of oxidative stress in vitro. Hence, TET2 might provide a new therapeutic approach for CRSwNP.PMID:38228132 | DOI:10.21053/ceo.2023.01340
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Authors: Source Type: research