Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy

CONCLUSIONS: Disulfiram and its metabolite represent an attractive pharmaceutical approach to induce ER stress in melanoma cells that potentiates the antitumor effect of MEK inhibition and may be an interesting candidate for combination therapy of BRAF WT melanoma.PMID:38263136 | PMC:PMC10804659 | DOI:10.1186/s13046-023-02941-5

Source: Clin Med Res - January 23, 2024 Category: Research Authors: Francisco Meraz-Torres Heike Niessner Sarah Pl öger Simon Riel Barbara Sch örg Nicolas Casadei Manfred Kneilling Martin Schaller Lukas Flatz Boris Macek Thomas Eigentler Olaf Rie ß Claus Garbe Teresa Amaral Tobias Sinnberg Source Type: research