Bioefficacy of Dietary Inclusion of < em > Nannochloropsis oculata < /em > on < em > Eimeria spp. < /em > Challenged Chicks: Clinical Approaches, Meat Quality, and Molecular Docking

Avian Pathol. 2024 Jan 29:1-30. doi: 10.1080/03079457.2024.2312133. Online ahead of print.ABSTRACTAbstractAnticoccidial drugs have been used to treat avian coccidiosis for almost a century, but drug resistance, bird harm, and food residues have produced human health issues. Therefore, Nannochloropsis oculata was studied as a potential chemotherapeutic alternative for broilers affected with coccidiosis. A total of 150 one-day-old male Cobb broiler chicks were treated as follows: G1-Ng: fed a basal diet; G2-Ps: challenged with Eimeria spp. oocysts and fed basal diet; G3-Clo: challenged and fed basal diet with clopidol; G4-NOa: challenged and fed 0.1% N. oculata in diet, and G5-NOb challenged and fed 0.2% N. oculata. Compared to G2-Ps, N. oculata in the diet significantly (p < 0.05) decreased dropping scores, lesion scores, and oocyst shedding in challenged chicks. Without affecting breast meat color metrics, N. oculata increased total n-3 PUFA, WHC, drip loss, cooking loss, and thawing loss in challenged birds. At 28 days of age, birds received 0.2% N. oculata had significantly (p < 0.05) higher serum levels of MDA, T-SOD, HDL, and LDL cholesterol compared to G2-Ps. Serum AST, ALT, and urea levels were all decreased when N. oculata (0.2%) was used as opposed to G2-Ps. Histopathological alterations and the number of developmental and degenerative stages of Eimeria spp. in the intestinal epithelium were dramatically reduced by 0.2% N. oculata compared to G2-Ps. Molecular do...
Source: Avian Pathology - Category: Pathology Authors: Source Type: research