Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition
Eur J Endocrinol. 2024 Jan 3;190(1):K1-K7. doi: 10.1093/ejendo/lvad179.ABSTRACTThe pathogenesis of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis was gradually revealed as cases emerged. Our comprehensive analysis, including all reported cases, identified a new instance of anti-PIT-1 hypophysitis postimmune checkpoint inhibitor therapy. All 9 patients exhibited extremely low growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) levels; 2 had a slightly atrophic pituitary gland; 4 had thymoma, and 5 had malignant neoplasms of diffuse large B-cell lymphoma (DLBCL) and other origins. Patients with thymoma showed multiple autoimmune diseases. HLA-A*24:02 and/or A*02:06 were present in six and DR53 in 5 cases analyzed. High anti-PIT-1 antibody titers and ectopic PIT-1 expression in the cytosol and nucleus of the tumor tissues were observed in patients with thymoma or DLBCL, whereas it was exclusively observed in the nuclei of a bladder cancer patient. These findings provide new insights into the pathophysiology of paraneoplastic autoimmune hypophysitis.PMID:38146732 | DOI:10.1093/ejendo/lvad179
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Shin Urai Genzo Iguchi Keitaro Kanie Hironori Bando Masaaki Yamamoto Yuka Oi Yuya Kashitani Keiji Iida Maki Kanzawa Hidenori Fukuoka Michiko Takahashi Yasushi Shintani Wataru Ogawa Yutaka Takahashi Source Type: research
More News: Autoimmune Disease | Bladder Cancer | Cancer | Cancer & Oncology | Endocrinology | Hormones | Lymphoma | Paraneoplastic Syndrome | Thyroid | Thyroid Cancer