GLP-1 metabolite GLP-1(9 –36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion

Conclusions/interpretationWe conclude that the GLP-1 metabolite GLP-1(9 –36) is a systemic inhibitor of glucagon secretion. We propose that the increase in circulating glucagon observed following genetic/pharmacological inactivation of glucagon signalling in mice and in people with type 2 diabetes reflects the removal of GLP-1(9–36)’s glucagonostatic action.Graphical Abstract
Source: Diabetologia - Category: Endocrinology Source Type: research