Causal relationship between inflammatory factors and cerebral small vessel disease: Univariate, multivariate, and summary ‐data‐based mendelian randomization analysis

ConclusionAccording to MR and SMR analysis, higher levels of TRAIL increased the risk of SVS by upregulating gene expression of KNG1 in brain cortex tissues. In addition, protective effects of E-selectin and IL-3a levels on WMPVS were regulated by increased DNA methylation of gene ABO in blood tissue.

https://onlinelibrary.wiley.com/doi/10.1002/brb3.3399?af=R

Source: Brain and Behavior - February 10, 2024 Category: Neurology Authors: Tian ‐Ci Qiao, Hao‐Yu Tian, Shi‐Zhe Shan, Li‐Li Shan, Zheng‐Yu Peng, Jia Ke, Meng‐Ting Li, Yang Wu, Yan Han Tags: ORIGINAL ARTICLE Source Type: research