The role of the CX3CL1/CX3CR1 axis as potential inflammatory biomarkers in subjects with periodontitis and rheumatoid arthritis: A systematic review

ConclusionVery few studies highlight the role of the CX3CL1/CX3CR1 axis in the pathogenesis of periodontitis; however, increased levels of these chemokines are observed in different biological samples (GCF, gingival tissue, saliva, and serum) from subjects with periodontitis and RA compared with their healthy controls. Future studies should focus on long-term follow-up of subjects and monitoring changes in cytokine levels before and after periodontal therapy to deduce an appropriate interval in health and disease conditions.

Source: Immunity, Inflammation and Disease - February 6, 2024 Category: Allergy & Immunology Authors: Mario A. Alarc ón‐Sánchez, Julieta S. Becerra‐Ruiz, Celia Guerrero‐Velázquez, Seyed A. Mosaddad, Artak Heboyan Tags: REVIEW ARTICLE Source Type: research