Pilot Study of Unrelated Donor (URD) Peripheral Stem Cell Transplant (PSCT) with CD45RA-Depleted Addback Following TCRab/CD19 Depletion in Pediatric Patients with Hematologic Malignancies

Ex vivo T lymphocyte depletion may decrease the risk of severe GVHD for unrelated donor SCT, but delayed immune reconstitution increases infectious risk. Addback of donor CD45RA (na ïve T cell)-depleted cells, CD45RO (memory T cells)-enriched, may accelerate immune recovery. In this pilot study we evaluated the feasibility and efficacy of CD45RA-depleted addback following TCRab/CD19-depleted unrelated donor PSCT in pediatric patients with hematologic malignancies (NCT03810196) .

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Caitlin W. Elgarten, Stephanie Heidemann, Jason L. Freedman, Stephan A. Grupp, Patricia Hankins, Stephan Kadauke, Yimei Li, Barbara McGlynn, Timothy S. Olson, Yongping Wang, Lisa Wray, Lei Wang, Alix E. Seif, Nancy J. Bunin Tags: 12 Source Type: research